For research use only. Not for therapeutic Use.
Usnoflast(CAT: I040770) is a selective phosphodiesterase 4 (PDE4) inhibitor with potent anti-inflammatory properties. By inhibiting PDE4, Usnoflast increases intracellular levels of cyclic AMP (cAMP), which leads to the suppression of pro-inflammatory cytokines and modulation of immune responses. This mechanism makes it a promising therapeutic candidate for the treatment of inflammatory and autoimmune diseases, including asthma, chronic obstructive pulmonary disease (COPD), and psoriasis. Usnoflast is being investigated for both its efficacy and improved safety profile compared to earlier PDE4 inhibitors. It serves as a valuable tool in inflammation research and the development of targeted therapies for chronic inflammatory conditions.
| CAS Number | 2455519-86-3 |
| Synonyms | 1-[(E)-2-[(2R)-1,2-dimethylpyrrolidin-2-yl]ethenyl]sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea |
| Molecular Formula | C21H29N3O3S |
| Purity | ≥95% |
| IUPAC Name | 1-[(E)-2-[(2R)-1,2-dimethylpyrrolidin-2-yl]ethenyl]sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea |
| InChI | InChI=1S/C21H29N3O3S/c1-21(10-5-12-24(21)2)11-13-28(26,27)23-20(25)22-19-17-8-3-6-15(17)14-16-7-4-9-18(16)19/h11,13-14H,3-10,12H2,1-2H3,(H2,22,23,25)/b13-11+/t21-/m1/s1 |
| InChIKey | HAMGPBKPACGWND-ZOXUKVPXSA-N |
| SMILES | CC1(CCCN1C)C=CS(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
