USP1-IN-2

• CAT Number: I042890
• CAS Number: 2098212-05-4
• Molecular Formula: C26H22F4N6O
• Molecular Weight: 510.49
• Purity: ≥95%
• Synonyms: 2-(3-fluoro-2-propan-2-ylphenyl)-9-[[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]-7H-purin-8-one
• InChI: InChI=1S/C26H22F4N6O/c1-14(2)21-17(5-4-6-18(21)27)22-31-11-19-24(34-22)36(25(37)32-19)12-15-7-9-16(10-8-15)23-33-20(13-35(23)3)26(28,29)30/h4-11,13-14H,12H2,1-3H3,(H,32,37)
• InChIKey: DCXQZTACMIBGMC-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(C=CC=C1F)C2=NC=C3C(=N2)N(C(=O)N3)CC4=CC=C(C=C4)C5=NC(=CN5C)C(F)(F)F

USP1-IN-2 (Compound I-193) is a potent ubiquitin-specific protease 1 (USP1) inhibitor with an IC50 of less than about 50 nM[1].

Reference

[1]. Alexandre Joseph Buckmelter, et al. Purinones as ubiquitin-specific protease 1 inhibitors. Patent US20170145012A1.