IU1（Cat No.:R061143）is a selective inhibitor of USP14, a deubiquitinating enzyme that regulates protein degradation via the proteasome. By inhibiting USP14, IU1 enhances proteasomal activity, promoting the degradation of misfolded or damaged proteins. This makes IU1 a valuable tool for research into neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, where impaired protein clearance plays a key role. Additionally, IU1’s ability to modulate the ubiquitin-proteasome pathway provides insights into potential therapeutic strategies for conditions linked to protein aggregation and cellular stress.
| Catalog Number | R061143 |
| CAS Number | 314245-33-5 |
| Synonyms | 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone |
| Molecular Formula | C₁₈H₂₁FN₂O |
| Purity | ≥95% |
| Target | DUB |
| Solubility | >10.9mg/mL in DMSO |
| Storage | Store at 4°C |
| IUPAC Name | 1-[1-(4-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-2-pyrrolidin-1-ylethanone |
| InChI | InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 |
| InChIKey | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3 |
| Reference | </br>1:Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer/’s disease. Kiprowska MJ, Stepanova A, Todaro DR, Galkin A, Haas A, Wilson SM, Figueiredo-Pereira ME.Biochim Biophys Acta. 2017 Apr 1;1863(6):1157-1170. doi: 10.1016/j.bbadis.2017.03.017. [Epub ahead of print] PMID: 28372990 </br>2:USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. Xu YH, Guo NL.Cell Mol Biol (Noisy-le-grand). 2014 Sep 7;60(2):50-4. PMID: 25198582 |
