USP7-IN-13

• CAT Number: I040069
• CAS Number: 2305046-93-7
• Molecular Formula: C24H28N4O3
• Molecular Weight: 420.50
• Purity: ≥95%
• Synonyms: 7-amino-3-[[4-hydroxy-1-[(3R)-3-phenylbutanoyl]piperidin-4-yl]methyl]quinazolin-4-one
• InChI: InChI=1S/C24H28N4O3/c1-17(18-5-3-2-4-6-18)13-22(29)27-11-9-24(31,10-12-27)15-28-16-26-21-14-19(25)7-8-20(21)23(28)30/h2-8,14,16-17,31H,9-13,15,25H2,1H3/t17-/m1/s1
• InChIKey: VMRPPHZDHZOHBB-QGZVFWFLSA-N
• SMILES: CC(CC(=O)N1CCC(CC1)(CN2C=NC3=C(C2=O)C=CC(=C3)N)O)C4=CC=CC=C4

USP7-IN-13 (Compound 101) is a USP7 inhibitor with an IC50 value of 0.2-1 μM, which can be used for the study of multiple myeloma[1].

Reference

[1]. Buhrlage, Sara, et al. “Novel usp7 inhibitors for treating multiple myeloma.” U.S. Patent. WO2019067503. 2019-04-04