USP7-IN-7

• CAT Number: I041796
• CAS Number: 2413944-70-2
• Molecular Formula: C27H28ClN3O3S
• Molecular Weight: 510.05
• Purity: ≥95%
• Synonyms: 3-[[7-[5-chloro-3-methyl-2-[[(2R)-morpholin-2-yl]methyl]phenyl]thieno[3,2-b]pyridin-2-yl]methyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione
• InChI: InChI=1S/C27H28ClN3O3S/c1-14-8-15(28)9-20(19(14)10-16-12-29-6-7-34-16)18-4-5-30-21-11-17(35-24(18)21)13-31-25(32)22-23(26(31)33)27(22,2)3/h4-5,8-9,11,16,22-23,29H,6-7,10,12-13H2,1-3H3/t16-,22?,23?/m1/s1
• InChIKey: DUAGQCVAGBJSHT-ZUTUBDCJSA-N
• SMILES: CC1=CC(=CC(=C1CC2CNCCO2)C3=C4C(=NC=C3)C=C(S4)CN5C(=O)C6C(C5=O)C6(C)C)Cl

USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].
USP7-IN-7 (0-1 μM) shows cytotoxicity against p53 wild-type blood cancer cell lines with CC50 values of 0.2, 0.2, 0.4 and 0.1 μM for M07e, OCI-AML5, MOLM13 and MM.IS, respectively[1].
USP7-IN-7 (0-2 μM) shows cytotoxicity against p53 wild-type neuroblastoma cell lines with CC50 values of 1.9, 0.6 and 0.5 μM for SH-SY5Y, CHP-134 and NB-1, respectively[1].
USP7-IN-7 (0-25 μM) shows cytotoxicity against p53-mutant cancer cell lines with CC50 values of 0.5, 0.2 and 0.2 μM for H526, LA-N-2 and SK-N-DZ, respectively[1].

Reference

[1]. Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.