For research use only. Not for therapeutic Use.
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1].
USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].
| Catalog Number | I044540 |
| CAS Number | 2009273-60-1 |
| Synonyms | 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)pyridin-3-yl]-N-methylbenzamide |
| Molecular Formula | C21H21N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H21N3O2/c1-3-17-18(13-4-6-15(7-5-13)21(26)23-2)12-24-20(22)19(17)14-8-10-16(25)11-9-14/h4-12,25H,3H2,1-2H3,(H2,22,24)(H,23,26) |
| InChIKey | GUXGBQOCJOOOFS-UHFFFAOYSA-N |
| SMILES | CCC1=C(C(=NC=C1C2=CC=C(C=C2)C(=O)NC)N)C3=CC=C(C=C3)O |
| Reference | [1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1. |
