USP8-IN-1

• CAT Number: I043669
• CAS Number: 2477650-96-5
• Molecular Formula: C18H21N5O3S
• Molecular Weight: 387.46
• Purity: ≥95%
• Synonyms: 4-(2-amino-4-methoxyphenyl)-N-(4-nitrophenyl)piperazine-1-carbothioamide
• InChI: InChI=1S/C18H21N5O3S/c1-26-15-6-7-17(16(19)12-15)21-8-10-22(11-9-21)18(27)20-13-2-4-14(5-3-13)23(24)25/h2-7,12H,8-11,19H2,1H3,(H,20,27)
• InChIKey: LYQOAIJZQPUZEF-UHFFFAOYSA-N
• SMILES: COC1=CC(=C(C=C1)N2CCN(CC2)C(=S)NC3=CC=C(C=C3)[N+](=O)[O-])N

USP8-IN-1 is a USP8 inhibitor with an IC50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI50 of 82.04 μM (CN111138358A; U10)[1].

Reference

[1]. Zhiyu Li, et al. USP8 inhibitor and preparation method and application thereof. CN111138358A.