Ustekinumab

For research use only. Not for therapeutic Use.

  • Cancer Immunotherapy,
  • CAT Number: I018815
  • CAS Number: 815610-63-0
  • Molecular Weight: 145625.97
  • Purity: ≥95%
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Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.
Ustekinumab is a human monoclonal antibody that prevents human IL-12 and IL-23 from binding to the IL-12Rβ1 receptor chain of IL-12 (IL-12Rβ1/β2) and IL-23 (IL-12Rβ1/23R) receptor complexes on the surface of natural killer cells and T-cells[1]. Ustekinumab is a human IgG1 kappa (κ) monoclonal antibody against the IL-12/IL-23 p40 subunit that prevents its interaction with IL-12Rβ1, thereby blocking subsequent signaling. The FcRn affinities at pH 6.0 fell in a narrow range for all 11 antibodies. The equilibrium dissociation constant (KD) is calculated relative to Ustekinumab (Ustekinumab=1.0)[2].


Catalog Number I018815
CAS Number 815610-63-0
Purity ≥95%
Reference

[1]. Montepaone M, et al. Profile of ustekinumab and its potential in the treatment of active psoriatic arthritis. Open Access Rheumatol. 2014 Feb 20;6:7-13.
 [Content Brief]

[2]. Schoch A, et al. Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5997-6002.
 [Content Brief]

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