UT-11

• CAT Number: I041374
• Molecular Formula: C17H19Cl2N3O2S
• Molecular Weight: 400.32
• Purity: ≥95%
• Synonyms: 1-(5,6-dichloro-1,3-benzothiazol-2-yl)-N-[(3R)-oxolan-3-yl]piperidine-4-carboxamide
• InChI: InChI=1S/C17H19Cl2N3O2S/c18-12-7-14-15(8-13(12)19)25-17(21-14)22-4-1-10(2-5-22)16(23)20-11-3-6-24-9-11/h7-8,10-11H,1-6,9H2,(H,20,23)/t11-/m1/s1
• InChIKey: CAIZZJVFQARMJL-LLVKDONJSA-N
• SMILES: C1CN(CCC1C(=O)NC2CCOC2)C3=NC4=CC(=C(C=C4S3)Cl)Cl

UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively[1].
UT-11 (10 mg/kg; i.p.; twice) dampens neuroinflammation in LPS (HY-D1056)-induced inflammation mouse model[1].

Reference

[1]. Sluter MN, et al. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599.
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