UT-B-IN-1

• CAT Number: I041809
• CAS Number: 892742-76-6
• Molecular Formula: C20H17N5O2S3
• Molecular Weight: 455.58
• Purity: ≥95%
• Synonyms: 10-(4-ethylphenyl)sulfonyl-N-(thiophen-2-ylmethyl)-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-amine
• InChI: InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22)
• InChIKey: UYFZCWXRMHSLTC-UHFFFAOYSA-N
• SMILES: CCC1=CC=C(C=C1)S(=O)(=O)C2=C3N=C(C4=C(N3N=N2)C=CS4)NCC5=CC=CS5

UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research[1].
UT-B-IN-1 (1-1000 nM) inhibits urea efflux in erythrocytes preloaded with urea with an IC50 value of 26.7 nM[1].
UT-B-IN-1 inhibits water transport in AQP1-null erythrocytes[1].
UT-B-IN-1 (0-10 μM;24 h) shows no cytotoxicity to MDCK cells[1].
UT-B-IN-1 (300 μg; i.p., once) increases urine output and reduces urine osmolality in mice with free access to water and food[1].

Reference

[1]. Yao C, et al. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration. J Am Soc Nephrol. 2012 Jul;23(7):1210-20.
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