For research use only. Not for therapeutic Use.
UU-T02 is a potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction. The β-catenin/T-cell factor (Tcf) protein−protein interaction (PPI) plays a critical role in the β-catenin signaling pathway which is hyperactivated in many cancers and fibroses. UU-T02 disrupted β-catenin/Tcf PPI with a Ki of 1.36 μM in the fluorescence polarization (FP) competitive inhibition assay and displayed 175- and 64-fold selectivity over β-catenin/E-cadherin and β-catenin/APC, respectively.
| Catalog Number | I037909 |
| CAS Number | 1500080-17-0 |
| Synonyms | UU-T02; UU-T-02; UU-T 02; UUT02; UUT-02; UUT 02; |
| Molecular Formula | C33H33ClN4O9 |
| Purity | 98% |
| Target | β-catenin |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-4-((S)-3-carboxy-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)propanamido)-5-methoxy-5-oxopentanoic acid |
| InChI | InChI=1S/C33H33ClN4O9/c1-47-33(46)25(10-11-29(40)41)37-32(45)27(17-30(42)43)38-31(44)26(13-18-6-7-19-4-2-3-5-20(19)12-18)36-28(39)16-23-15-21-14-22(34)8-9-24(21)35-23/h2-9,12,14-15,25-27,35H,10-11,13,16-17H2,1H3,(H,36,39)(H,37,45)(H,38,44)(H,40,41)(H,42,43)/t25-,26-,27-/m0/s1 |
| InChIKey | SGTICZUBRHDIMI-QKDODKLFSA-N |
| SMILES | O=C(O)CC[C@H](NC([C@@H](NC([C@@H](NC(CC(N1)=CC2=C1C=CC(Cl)=C2)=O)CC3=CC=C4C=CC=CC4=C3)=O)CC(O)=O)=O)C(OC)=O |
| Reference | Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction |
