UUN-14238

• CAT Number: I037905
• CAS Number: 2222114-23-8
• Molecular Formula: C17H18ClFN4O4
• Molecular Weight: 396.8034
• Purity: 98%
• Synonyms: UUN-14238; UUN14238; UUN 14238; Pomalidomide 5'-fluoro-6'-piperazine
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
• InChI: InChI=1S/C17H17FN4O4.ClH/c18-11-7-9-10(8-13(11)21-5-3-19-4-6-21)17(26)22(16(9)25)12-1-2-14(23)20-15(12)24;/h7-8,12,19H,1-6H2,(H,20,23,24);1H
• InChIKey: UQDWELYJNPCIGK-UHFFFAOYSA-N
• SMILES: FC1=C(C=C2C(N(C3CCC(NC3=O)=O)C(C2=C1)=O)=O)N4CCNCC4.Cl

UUN-14238(CAT: I037905) is a small molecule that has been developed as a functionalized cereblon ligand for PROTAC (proteolysis-targeting chimeras) research and development. It is designed to serve as an E3 ligase ligand with a terminal piperazine that can be used for further chemistry to create protein degraders with rigid linkers. UUN-14238 is one of several functionalized tool molecules that have been developed for PROTAC degrader research and development. These molecules have the potential to enable the targeted degradation of disease-causing proteins and offer a promising approach to developing new therapeutics.