V-0219 hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I041423
  • CAS Number: 2922283-73-4
  • Molecular Formula: C20H26ClF3N4O2
  • Molecular Weight: 446.89
  • Purity: ≥95%
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V-0219 hydrochloride (Compound 9) is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). V-0219 hydrochloride can be used for obesity-associated diabetes research[1].


Catalog Number I041423
CAS Number 2922283-73-4
Synonyms

4-[[1-[[3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]methyl]piperidin-3-yl]methyl]morpholine;hydrochloride

Molecular Formula C20H26ClF3N4O2
Purity ≥95%
InChI InChI=1S/C20H25F3N4O2.ClH/c21-20(22,23)17-5-3-16(4-6-17)19-24-18(29-25-19)14-27-7-1-2-15(13-27)12-26-8-10-28-11-9-26;/h3-6,15H,1-2,7-14H2;1H
InChIKey PTRIYHLSBQMDQM-UHFFFAOYSA-N
SMILES C1CC(CN(C1)CC2=NC(=NO2)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4.Cl
Reference

[1]. Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for “Diabesity”. J Med Chem. 2022 Apr 14;65(7):5449-5461.
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