For research use only. Not for therapeutic Use.
VA012 is a positive allosteric modulator of the serotonin 5-HT2C receptor with an EC50 value of 16 nM. VA012 exhibits enhanced efficacy dose-dependently, no significant off-target activities, and low competition with the endogenous agonist or other orthosteric ligands.
KEYWORDS: VA012 | supplier | PAM of 5-HT2C | VA 012 | VA-012 | CAS [885898-58-8] | Serotonin | 5-HT2C | PAM | Receptors | Obesity
| Catalog Number | I037922 |
| CAS Number | 885898-58-8 |
| Molecular Formula | C21H19N3 |
| Purity | ≥95% |
| IUPAC Name | N-[(1-benzylindol-3-yl)methyl]pyridin-3-amine |
| InChI | InChI=1S/C21H19N3/c1-2-7-17(8-3-1)15-24-16-18(20-10-4-5-11-21(20)24)13-23-19-9-6-12-22-14-19/h1-12,14,16,23H,13,15H2 |
| SMILES | C1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)CNC4=CN=CC=C4 |
| Reference | J García-Cárceles et al. A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity. J Med Chem. 2017 Dec 14;60(23):9575-9584. |
