For research use only. Not for therapeutic Use.
Vaborbactam（Cat No.:I009976）is a boronic acid-based beta-lactamase inhibitor developed to combat antibiotic-resistant bacterial infections, particularly those caused by carbapenem-resistant Enterobacteriaceae (CRE). It works by inhibiting class A and some class C beta-lactamases, enzymes that bacteria produce to inactivate antibiotics. Often combined with meropenem, vaborbactam restores the antibiotic’s efficacy against resistant bacteria, especially in severe urinary tract infections (UTIs) and complicated intra-abdominal infections. Vaborbactam is highly valued in clinical and pharmaceutical research, addressing the urgent need for treatments against multidrug-resistant pathogens.
| Catalog Number | I009976 |
| CAS Number | 1360457-46-0 |
| Synonyms | RPX-7009; RPX7009; RPX 7009; MP-7009; MP7009; MP 7009; REBO-07; MP-7; Vaborbactam;2-((3R,6S)-2-hydroxy-3-(2-(thiophen-2-yl)acetamido)-1,2-oxaborinan-6-yl)acetic acid |
| Molecular Formula | C12H16BNO5S |
| Purity | ≥95% |
| Target | beta-lactamase inhibitor |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 2-[(3R,6S)-2-hydroxy-3-[(2-thiophen-2-ylacetyl)amino]oxaborinan-6-yl]acetic acid |
| InChI | InChI=1S/C12H16BNO5S/c15-11(7-9-2-1-5-20-9)14-10-4-3-8(6-12(16)17)19-13(10)18/h1-2,5,8,10,18H,3-4,6-7H2,(H,14,15)(H,16,17)/t8-,10-/m0/s1 |
| InChIKey | IOOWNWLVCOUUEX-WPRPVWTQSA-N |
| SMILES | B1([C@H](CC[C@H](O1)CC(=O)O)NC(=O)CC2=CC=CS2)O |
| Reference | </br>1:Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects. Griffith DC, Loutit JS, Morgan EE, Durso S, Dudley MN.Antimicrob Agents Chemother. 2016 Sep 23;60(10):6326-32. doi: 10.1128/AAC.00568-16. Print 2016 Oct. PMID: 27527080 Free PMC Article</br>2:Effect of the β-Lactamase Inhibitor Vaborbactam Combined with Meropenem against Serine Carbapenemase-Producing Enterobacteriaceae. Castanheira M, Rhomberg PR, Flamm RK, Jones RN.Antimicrob Agents Chemother. 2016 Aug 22;60(9):5454-8. doi: 10.1128/AAC.00711-16. Print 2016 Sep. PMID: 27381386 Free PMC Article |
