VAL-083

• CAT Number: I002774
• CAS Number: 23261-20-3
• Molecular Formula: C6H10O4
• Molecular Weight: 146.14
• Purity: ≥95%
• Synonyms: (1S,2R)-1-[(2S)-oxiran-2-yl]-2-[(2R)-oxiran-2-yl]ethane-1,2-diol
• Target: DNA Alkylator/Crosslinker
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 5 uM (inhibit U251, SF188, T98G cell growth in monolayer after 72h) [1].

VAL-083 (Cat.No:I002774) is a chemotherapeutic agent being investigated for its potential in the treatment of various cancers, particularly glioblastoma multiforme (GBM). It is a bifunctional alkylating agent that induces DNA damage and cell death. Clinical trials have shown promising results, making VAL-083 a candidate for further research in cancer therapy.

Reference

[1]. Fotovati A, Hu K J, Wakimoto H, VAL-083, A NOVEL N7 ALKYLATING AGENT, SURPASSES TEMOZOLOMIDE ACTIVITY AND INHIBITS CANCER STEM CELLS, PROVIDING A NEW POTENTIAL TREATMENT OPTION FOR GLIOBLASTOMA MULTIFORME. Neuro-oncology, 2012, 14, AbsET-37, Suppl. 6
[2]. Fotovati A, Hu K J, Wakimoto H, VAL-083, A NOVEL N7 ALKYLATING AGENT, SURPASSES TEMOZOLOMIDE ACTIVITY AND INHIBITS CANCER STEM CELLS, PROVIDING A NEW POTENTIAL TREATMENT OPTION FOR GLIOBLASTOMA MULTIFORME. Neuro-oncology, 2012, 14, AbsET-37, Suppl. 6