Val-Ala-PAB-MMAE

For research use only. Not for therapeutic Use.

  • CAT Number: I040794
  • CAS Number: 1912408-92-4
  • Molecular Formula: C55H88N8O11
  • Molecular Weight: 1037.33
  • Purity: ≥95%
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Val-Ala-PAB-MMAE(CAT: I040794) is a cleavable linker-drug conjugate widely used in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. It includes a Val-Ala dipeptide linker sensitive to lysosomal enzymes, a self-immolative PAB (p-aminobenzyl carbamate) spacer, and MMAE (monomethyl auristatin E), a highly potent antimitotic agent. Once the ADC is internalized by cancer cells, the linker is enzymatically cleaved, releasing free MMAE to inhibit tubulin polymerization, leading to cell cycle arrest and apoptosis. Val-Ala-PAB-MMAE offers a powerful platform for delivering cytotoxic agents specifically to tumor cells, maximizing therapeutic efficacy while minimizing off-target toxicity in healthy tissues.


CAS Number 1912408-92-4
Synonyms

[4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate

Molecular Formula C55H88N8O11
Purity ≥95%
IUPAC Name [4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate
InChI InChI=1S/C55H88N8O11/c1-16-34(8)47(42(72-14)29-43(64)63-28-20-23-41(63)49(73-15)35(9)50(66)57-36(10)48(65)39-21-18-17-19-22-39)61(12)54(70)45(32(4)5)60-53(69)46(33(6)7)62(13)55(71)74-30-38-24-26-40(27-25-38)59-51(67)37(11)58-52(68)44(56)31(2)3/h17-19,21-22,24-27,31-37,41-42,44-49,65H,16,20,23,28-30,56H2,1-15H3,(H,57,66)(H,58,68)(H,59,67)(H,60,69)/t34-,35+,36+,37-,41-,42+,44-,45-,46-,47-,48+,49+/m0/s1
InChIKey MTXKKTCVANNYBH-AXWSPWQFSA-N
SMILES CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C(=O)OCC3=CC=C(C=C3)NC(=O)C(C)NC(=O)C(C(C)C)N

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