Val-Ala-PABC-Exatecan

• CAT Number: I040945
• CAS Number: 2845164-91-0
• Molecular Formula: C40H43FN6O8
• Molecular Weight: 754.80
• Purity: ≥95%
• Synonyms: [4-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamate
• InChI: InChI=1S/C40H43FN6O8/c1-6-40(53)26-13-30-34-24(15-47(30)37(50)25(26)17-54-38(40)51)32-28(12-11-23-19(4)27(41)14-29(45-34)31(23)32)46-39(52)55-16-21-7-9-22(10-8-21)44-35(48)20(5)43-36(49)33(42)18(2)3/h7-10,13-14,18,20,28,33,53H,6,11-12,15-17,42H2,1-5H3,(H,43,49)(H,44,48)(H,46,52)/t20-,28-,33-,40-/m0/s1
• InChIKey: ZACAMCPLQSLRJF-PICQSYHMSA-N
• SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)OCC7=CC=C(C=C7)NC(=O)C(C)NC(=O)C(C(C)C)N)O

Val-Ala-PABC-Exatecan (Cat No.: I040945) is an antibody-drug conjugate (ADC) payload linker combining a dipeptide linker (Val-Ala), a self-immolative spacer (PABC), and the potent topoisomerase I inhibitor Exatecan. Upon internalization and enzymatic cleavage within target cells, Exatecan is released to induce DNA damage and apoptosis. This cleavable linker system ensures selective cytotoxicity in cancer cells while minimizing systemic toxicity. Val-Ala-PABC-Exatecan is a valuable tool for developing and optimizing ADCs in oncology research. For research use only in preclinical and laboratory settings.