Val-Cit

• CAT Number: I016150
• CAS Number: 159858-33-0
• Molecular Formula: C11H22N4O4
• Molecular Weight: 274.32
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-5-(carbamoylamino)pentanoic acid
• InChI: InChI=1S/C11H22N4O4/c1-6(2)8(12)9(16)15-7(10(17)18)4-3-5-14-11(13)19/h6-8H,3-5,12H2,1-2H3,(H,15,16)(H,17,18)(H3,13,14,19)/t7-,8-/m0/s1
• InChIKey: AGGWFDNPHKLBBV-YUMQZZPRSA-N
• SMILES: CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)O)N

Val-Cit is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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