For research use only, not for therapeutic use.
Val-Lys(Boc)-PAB is a ADC linker. Val-Lys(Boc)-PAB was used to prepare camptothecin peptide conjugates as antitumor agents (WO 2019195665). It was used as a non-linear self-immolative linker for reducing hydrophobicity of antibody-drug conjugates for cancer therapy (WO 2018069375).
| Catalog Number | I037948 |
| CAS Number | 1432969-86-2 |
| Synonyms | Val-Lys(Boc)-PAB; |
| Molecular Formula | C23H38N4O5 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | tert-butyl ((S)-5-((S)-2-amino-3-methylbutanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate |
| InChI | InChI=1S/C23H38N4O5/c1-15(2)19(24)21(30)27-18(8-6-7-13-25-22(31)32-23(3,4)5)20(29)26-17-11-9-16(14-28)10-12-17/h9-12,15,18-19,28H,6-8,13-14,24H2,1-5H3,(H,25,31)(H,26,29)(H,27,30)/t18-,19-/m0/s1 |
| InChIKey | BPDGVDDLTIMMLY-OALUTQOASA-N |
| SMILES | CC(C)(OC(NCCCC[C@@H](C(NC1=CC=C(CO)C=C1)=O)NC([C@H](C(C)C)N)=O)=O)C |
