Val-Lys(Boc)-PAB

• CAT Number: I037948
• CAS Number: 1432969-86-2
• Molecular Formula: C23H38N4O5
• Molecular Weight: 450.58
• Purity: 98%
• Synonyms: Val-Lys(Boc)-PAB
• Target: ADC Linker
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: tert-butyl ((S)-5-((S)-2-amino-3-methylbutanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate
• InChI: InChI=1S/C23H38N4O5/c1-15(2)19(24)21(30)27-18(8-6-7-13-25-22(31)32-23(3,4)5)20(29)26-17-11-9-16(14-28)10-12-17/h9-12,15,18-19,28H,6-8,13-14,24H2,1-5H3,(H,25,31)(H,26,29)(H,27,30)/t18-,19-/m0/s1
• InChIKey: BPDGVDDLTIMMLY-OALUTQOASA-N
• SMILES: CC(C)(OC(NCCCC[C@@H](C(NC1=CC=C(CO)C=C1)=O)NC([C@H](C(C)C)N)=O)=O)C

Val-Lys(Boc)-PAB is a ADC linker. Val-Lys(Boc)-PAB was used to prepare camptothecin peptide conjugates as antitumor agents (WO 2019195665). It was used as a non-​linear self-​immolative linker for reducing hydrophobicity of antibody-​drug conjugates for cancer therapy (WO 2018069375).