Valacyclovir（Cat No.:I000991） is an antiviral medication commonly used for the treatment and management of herpes infections, including herpes simplex (cold sores), herpes zoster (shingles), and herpes B. It belongs to a class of drugs called nucleoside analogues, which work by inhibiting the replication of the virus. Valacyclovir is converted into its active form, acyclovir, in the body, which then interferes with the viral DNA synthesis, thereby reducing the severity and duration of the outbreaks. It is an effective and well-tolerated option for controlling and preventing recurrent herpes infections.
| Catalog Number | I000991 |
| CAS Number | 124832-26-4 |
| Synonyms | 2-((2-amino-6-oxo-3H-purin-9(6H)-yl)methoxy)ethyl 2-amino-3-methylbutanoate |
| Molecular Formula | C13H20N6O4 |
| Purity | ≥95% |
| Target | HSV |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 2.9 microg/ml (for HSV-1 W). |
| IUPAC Name | 2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate |
| InChI | InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 |
| InChIKey | HDOVUKNUBWVHOX-QMMMGPOBSA-N |
| SMILES | CC(C)C(C(=O)OCCOCN1C=NC2=C1NC(=NC2=O)N)N |
| Reference | </br>1:Use of High-Dose Oral Valacyclovir During an Intravenous Acyclovir Shortage: A Retrospective Analysis of Tolerability and Drug Shortage Management. McLaughlin MM, Sutton SH, Jensen AO, Esterly JS.Infect Dis Ther. 2017 Apr 17. doi: 10.1007/s40121-017-0157-y. [Epub ahead of print] PMID: 28417331 </br>2:Valacyclovir as Initial Treatment for Acute Retinal Necrosis: A Pharmacokinetic Modeling and Simulation Study. Liu T, Jain A, Fung M, Vinnard C, Ivaturi V.Curr Eye Res. 2017 Mar 30:1-4. doi: 10.1080/02713683.2016.1231323. [Epub ahead of print] PMID: 28358222 </br>3:Occurrence of equine coital exanthema (ECE) in stallions in Japan and effectiveness of treatment with valacyclovir for ECE. Toishi Y, Tsunoda N, Kirisawa R.J Vet Med Sci. 2017 Mar 23;79(3):632-635. doi: 10.1292/jvms.16-0511. Epub 2017 Jan 26. PMID: 28123140 Free PMC Article</br>4:Acute renal injury induced by valacyclovir hydrochloride: A case report. Zhang Y, Cong Y, Teng Y.Exp Ther Med. 2016 Dec;12(6):4025-4028. doi: 10.3892/etm.2016.3905. Epub 2016 Nov 15. PMID: 28101180 Free PMC Article</br>5:Herpes Zoster in Autologous Hematopoietic Cell Transplant Recipients in the Era of Acyclovir or Valacyclovir Prophylaxis and Novel Treatment and Maintenance Therapies. Sahoo F, Hill JA, Xie H, Leisenring W, Yi J, Goyal S, Kimball LE, Lee I, Seo S, Davis C, Pergam SA, Flowers ME, Liaw KL, Holmberg L, Boeckh M.Biol Blood Marrow Transplant. 2017 Mar;23(3):505-511. doi: 10.1016/j.bbmt.2016.12.620. Epub 2016 Dec 28. PMID: 28039754 </br>6:Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial. Wald A, Timmler B, Magaret A, Warren T, Tyring S, Johnston C, Fife K, Selke S, Huang ML, Stobernack HP, Zimmermann H, Corey L, Birkmann A, Ruebsamen-Schaeff H.JAMA. 2016 Dec 20;316(23):2495-2503. doi: 10.1001/jama.2016.18189. Erratum in: JAMA. 2017 Feb 14;317(6):648. PMID: 27997653 </br>7:FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial. Tyring SK, Lee P, Hill GT Jr, Silverfield JC, Moore AY, Matkovits T, Sullivan-Bolyai J.J Med Virol. 2017 Jul;89(7):1255-1264. doi: 10.1002/jmv.24750. Epub 2016 Dec 26. PMID: 27943311 </br>8:Valacyclovir versus acyclovir for the treatment of herpes zoster ophthalmicus in immunocompetent patients. Schuster AK, Harder BC, Schlichtenbrede FC, Jarczok MN, Tesarz J.Cochrane Database Syst Rev. 2016 Nov 14;11:CD011503. Review. PMID: 27841441 </br>9:Efficacy of oral valacyclovir in cytomegalovirus-infected fetuses. Straface G, Zanardo V, De Santis M.Am J Obstet Gynecol. 2017 Feb;216(2):196. doi: 10.1016/j.ajog.2016.09.093. Epub 2016 Sep 22. No abstract available. PMID: 27667766 </br>10:Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. Polansky H, Javaherian A, Itzkovitz E.Drug Des Devel Ther. 2016 Aug 29;10:2713-22. doi: 10.2147/DDDT.S112852. eCollection 2016. PMID: 27621592 Free PMC Article |
