Valbenazine tosylate

• CAT Number: I014826
• CAS Number: 1639208-54-0
• Molecular Formula: C38H54N2O10S2
• Molecular Weight: 762.97
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC

Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).

Reference

[1] Citrome L. Expert Rev Neurother. 2018, 18(4):323-332.
[2] Grigoriadis DE, et al. J Pharmacol Exp Ther. 2017, 361(3):454-461.
[3] Stepan Uhlyar, et al. P T. 2018, 43(6): 328–331.