Valinomycin

• CAT Number: R051590
• CAS Number: 2001-95-8
• Molecular Formula: C54H90N6O18
• Molecular Weight: 1111.30
• Purity: ≥95%
• Synonyms: 3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone; 1Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-?hydroxyisovaleryl-D-v
• Target: Potassium Channel
• Solubility: Soluble in DMSO > 10 mM
• Storage: Desiccate at -20C
• IUPAC Name: (3S,6S,9R,12R,15S,18S,21R,24R,27S,30S,33R,36R)-6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
• InChI: InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChIKey: FCFNRCROJUBPLU-DNDCDFAISA-N
• SMILES: C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

Valinomycin（Cat No.:R051590）is a naturally occurring cyclic peptide antibiotic produced by Streptomyces species, known for its selective ionophore activity, particularly transporting potassium ions across lipid membranes. By disrupting ion gradients, it affects cellular processes, making it valuable in studying ion transport and membrane potential. Valinomycin’s high affinity for potassium makes it useful in biochemistry and physiology for examining cellular ion homeostasis. Although toxic to mammalian cells, it has antimicrobial and antiviral properties, and its unique mechanism has led to research into potential applications in targeted therapies and biochemical research.

Reference

K+-selective nanospheres: maximising response range and minimising response time. Ruedas-Rama M.J. & Hall E.A. Analyst. 2006, 131, 1282.Potentiometric combination ion/carbon dioxide sensors for in vitro and in vivo blood measurements. Collison M.E. et al. Anal Chem. 1989, 61, 2365.