Valproic acid

• CAT Number: I005748
• CAS Number: 99-66-1
• Molecular Formula: C8H16O2
• Molecular Weight: 144.21
• Purity: ≥95%
• Synonyms: 2-propylpentanoic acid
• Target: HDAC
• Solubility: 10mM in water
• Storage: Store at -20C
• IC50: 10 uM (Hela, 24h)
• InChI: InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
• InChIKey: NIJJYAXOARWZEE-UHFFFAOYSA-N
• SMILES: CCCC(CCC)C(=O)O

Valproic acid (Cat No.:I005748) is not only an antiepileptic drug but also a histone deacetylase (HDAC) inhibitor. HDACs are enzymes that remove acetyl groups from histone proteins, leading to chromatin compaction and gene silencing. By inhibiting HDACs, valproic acid promotes histone acetylation, which results in a more relaxed chromatin structure and increased gene transcription. This epigenetic modulation can have various effects on cellular processes, including the regulation of gene expression involved in cell growth, differentiation, and apoptosis. Valproic acid’s HDAC inhibitory activity has been explored in the field of cancer research and other therapeutic applications beyond its antiepileptic properties.

Reference

[1]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. 


[2]. Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. 


[3]. Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50.


[4]. Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10.


[5]. Nanau RM, et al. Adverse drug reactions induced by valproic acid. Clin Biochem. 2013 Oct;46(15):1323-38.