Vanin-1-IN-3

• CAT Number: I043617
• CAS Number: 2940964-70-3
• Molecular Formula: C17H22F3NO5
• Molecular Weight: 377.36
• Purity: ≥95%
• Synonyms: (2R)-2,4-dihydroxy-3,3-dimethyl-N-[3-oxo-4-[4-(trifluoromethoxy)phenyl]butyl]butanamide
• InChI: InChI=1S/C17H22F3NO5/c1-16(2,10-22)14(24)15(25)21-8-7-12(23)9-11-3-5-13(6-4-11)26-17(18,19)20/h3-6,14,22,24H,7-10H2,1-2H3,(H,21,25)/t14-/m0/s1
• InChIKey: RSTKBZUZEJDDPA-AWEZNQCLSA-N
• SMILES: CC(C)(CO)C(C(=O)NCCC(=O)CC1=CC=C(C=C1)OC(F)(F)F)O

Vanin-1-IN-3 (OMP-7) is a vanin-1 inhibitor with an IC50 of 0.038 μM[1].
Vanin-1-IN-3 (OMP-7) (10 mg/kg) exhibits potent activity against both serum and renal vanin-1 in vivo (hamsters)[1].

Reference

[1]. Yoneyama H, et al. Design, synthesis, and evaluation of new vanin-1 inhibitors based on RR6. Bioorg Med Chem. 2022 Jul 1;65:116791.
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