For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Vanoxerine 2 Hcl(GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).<br>IC50 value:<br>Target: Dopamine reuptake inhibitor<br>At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.</p>
| Catalog Number | I004536 |
| CAS Number | 67469-78-7 |
| Synonyms | 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride |
| Molecular Formula | C28H34Cl2F2N2O |
| Purity | ≥95% |
| Target | Dopamine Transporter |
| Solubility | DMSO: ≤ 9.4 mg/mL |
| Storage | Store at -20C |
| IUPAC Name | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride |
| InChI | InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H |
| InChIKey | MIBSKSYCRFWIRU-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl |
| Reference | </br>1:[Pharmacological effects of the novel dopamine uptake inhibitor 1-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-4-(3-phenylpropyl) piperazine dihydrochloride (I-893) on the central nervous system]. Nagase T, Hotta K, Morita S, Sakai K, Yamane M, Omote M, Mizusawa H.Nihon Yakurigaku Zasshi. 1991 Aug;98(2):121-41. Japanese. PMID: 1833294 </br>2:[Effects of 1-[2-[bis(fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl) piperazine dihydrochloride (I-893) on turnover of dopamine and norepinephrine in the brain]. Nagase T, Ishiko J, Takaori S.Nihon Yakurigaku Zasshi. 1987 Aug;90(2):105-14. Japanese. PMID: 3119439 |
