For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Vanoxerine (GBR12909) is a potent and selective DRI (Dopamine reuptake inhibitor).<br>IC50 value:<br>Target: Dopamine reuptake inhibitor<br>At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels.[14] By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine. Vanoxerine is a potentially effective treatment for cardiac arrhythmias. A significant cause of cardiac arrhythmias is reentry, an electrophysiologic event in which the proliferating signal that refuses to terminate, and endures to reexcite the heart after the refractory period.</p>
| Catalog Number | I004535 |
| CAS Number | 67469-69-6 |
| Synonyms | 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine |
| Molecular Formula | C28H32F2N2O |
| Purity | ≥95% |
| Target | Dopamine Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
