For research use only. Not for therapeutic Use.
Vapendavir Diphosphate（Cat No.:I017258）is the active metabolite of Vapendavir, a potent antiviral agent targeting rhinoviruses and enteroviruses. It functions as a capsid binder, stabilizing the viral capsid and preventing the release of viral RNA, thereby halting replication. Vapendavir Diphosphate is particularly effective against picornaviruses, making it a valuable tool in respiratory virus research and antiviral drug development. Its mechanism of action, combined with its broad-spectrum activity, supports studies on viral pathogenesis, resistance mechanisms, and the exploration of novel therapeutic strategies for combating viral infections, including the common cold.
| Catalog Number | I017258 |
| CAS Number | 1198151-75-5 |
| Molecular Formula | C₂₁H₃₂N₄O₁₁P₂ |
| Purity | ≥95% |
| Target | Enterovirus |
| IUPAC Name | 3-ethoxy-6-[2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy]-1,2-benzoxazole;phosphoric acid |
| InChI | InChI=1S/C21H26N4O3.2H3O4P/c1-3-26-21-18-6-5-17(14-19(18)28-24-21)27-13-10-16-8-11-25(12-9-16)20-7-4-15(2)22-23-20;2*1-5(2,3)4/h4-7,14,16H,3,8-13H2,1-2H3;2*(H3,1,2,3,4) |
| InChIKey | MIUFDXZDQWMWRR-UHFFFAOYSA-N |
| SMILES | CCOC1=NOC2=C1C=CC(=C2)OCCC3CCN(CC3)C4=NN=C(C=C4)C.OP(=O)(O)O.OP(=O)(O)O |
| Reference | [1]. Tijsma A, et al. The capsid binder Vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replication. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2.<br>[2]. Sun L, et al. Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5. |
