Vardenafil dihydrochloride

• CAT Number: I009999
• CAS Number: 224789-15-5
• Molecular Formula: C23H32N6O4S.2HCl
• Molecular Weight: 561.52
• Purity: ≥95%
• IUPAC Name: 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride
• InChI: InChI=1S/C23H32N6O4S.2ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);2*1H
• SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl.Cl

Vardenafil dihydrochloride is a highly potent, selective and orally bioavailable cGMP phosphodiesterase (PDE5) inhibitor with IC50 values of 180 nM and 0.7 nM for PDE1 and PDE5, respectively.
Keywords: Vardenafil dihydrochloride | supplier | PDE5 inhibitor | BAY 38–9456 | CAS [224789-15-5] | [224785-90-4] | [224785-91-5] | [330808-88-3] | cGMP | PDE | Inhibitor | Enzymes | Erectile dysfunction

Reference

H Haning et al. Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors. Bioorg Med Chem Lett. 2002 Mar 25;12(6):865-8.