Varoglutamstat

• CAT Number: I047512
• CAS Number: 1276021-65-8
• Molecular Formula: C19H20N4O2
• Molecular Weight: 336.39
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCCOC1=CC=C(C=C1)C2CNC(=O)N2C3=CC4=C(C=C3)N=CN4

Varoglutamstat (PQ912) is an inhibitor of glutaminyl cyclase (QC), inhibiting human glutaminyl cyclase (hQC) activity with a Ki of 25 nM (pH 8.0). It reduces pyroglutamyl-Aβ (pE-Aβ) levels and can be used in Alzheimer’s disease research.

Reference

[1] Hoffmann T, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):119-130.