Vasopressin antagonist 1867

• CAT Number: I047572
• CAS Number: 909391-88-4
• Molecular Formula: C28H36N4O4
• Molecular Weight: 492.61
• Purity: ≥95%
• IUPAC Name: 2-[2-(3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)quinazolin-3-yl]-N-propan-2-ylacetamide
• InChI: InChI=1S/C28H36N4O4/c1-20(2)29-26(33)19-32-27(21-9-7-10-22(17-21)35-3)30-25-12-11-23(18-24(25)28(32)34)36-16-8-15-31-13-5-4-6-14-31/h7,9-12,17-18,20H,4-6,8,13-16,19H2,1-3H3,(H,29,33)
• SMILES: CC(C)NC(=O)CN1C(=NC2=C(C1=O)C=C(C=C2)OCCCN3CCCCC3)C4=CC(=CC=C4)OC

Orally available and selective V1b receptor antagonist (IC50 value 3 nM for hV1b inhibition, exhibiting >1000-fold selectivity over hV1a, hV2, and hOT).
A useful tool to study Vasopressin 1B receptor pharmacology.
KEYWORDS: Vasopressin antagonist 1867 | supplier | V1b antagonist | Compound 12i | CAS [909391-88-4] | Vasopressin | orally available | hypothalamic | pituitary | adrenal | HPA-axis | corticotrophin | neuroendocrine | antidepressant | anxiolytic | MSD | Akzo Nobel

Reference

SE Napier et al. Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1871-5.