For research use only. Not for therapeutic Use.
Potent VEGFR inhibitor (IC<sub>50</sub> values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs <em>in vitro</em> and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-<span class=/’symbol/’>β</span>, c-Kit and c-Fms. Potent aromatase inhibitor (IC<sub>50</sub> = 50 nM). Orally available.
| Catalog Number | I011272 |
| CAS Number | 212142-18-2 |
| Synonyms | Alternative Names: CGP 79787D, PTK787/ZK222584 |
| Molecular Formula | C24H21ClN4O4 |
| Purity | ≥95% |
| Target | VEGFR |
| Solubility | Soluble to 100 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | butanedioic acid;N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine |
| InChI | InChI=1S/C20H15ClN4.C4H6O4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;5-3(6)1-2-4(7)8/h1-12H,13H2,(H,23,25);1-2H2,(H,5,6)(H,7,8) |
| InChIKey | LLDWLPRYLVPDTG-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.C(CC(=O)O)C(=O)O |
