VEGFR2 Kinase Inhibitor I

• CAT Number: M137895
• CAS Number: 15966-93-5
• Molecular Formula: C18H18N2O3
• Molecular Weight: 310.353
• Purity: ≥95%
• Synonyms: SU 5408
• Target: VEGFR
• Storage: -20°C
• IUPAC Name: ethyl 2,4-dimethyl-5-[(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxylate
• InChI: InChI=1S/C18H18N2O3/c1-4-23-18(22)16-10(2)15(19-11(16)3)9-13-12-7-5-6-8-14(12)20-17(13)21/h5-9,19H,4H2,1-3H3,(H,20,21)
• InChIKey: PMUJUSJUVIXDQC-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=C1C)C=C2C3=CC=CC=C3NC2=O)C

Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor I is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM). It has little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC50 > 100 µM).