For research use only. Not for therapeutic Use.
Vem-bisamide-2 is a BRAF-V600E degrader. Degradation of BRAF-V600E was verified to be dependent on the ubiquitin proteasome system. Chemically Vem-bisamide-2 contains two molecule of Vemurafenib. (Vemurafenib, cat#202271, also known as PLX4032, RG7204 or RO5185426, is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E)).
| Catalog Number | I037999 |
| Synonyms | Vem-bisamide-2; Vemurafenib dimer, PLX4032 dimer; PLX-4032 dimer; PLX 4032 dimer; RG7204 dimer; RG-7204 dimer ; RG 7204 dimer ; RO5185426 dimer |
| Molecular Formula | C52H50F4N8O9S2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2,2'-oxybis(N-(4-(3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)benzyl)acetamide) |
| InChI | InChI=1S/C52H50F4N8O9S2/c1-3-17-74(69,70)63-41-15-13-39(53)45(47(41)55)49(67)37-25-61-51-35(37)19-33(23-59-51)31-9-5-29(6-10-31)21-57-43(65)27-73-28-44(66)58-22-30-7-11-32(12-8-30)34-20-36-38(26-62-52(36)60-24-34)50(68)46-40(54)14-16-42(48(46)56)64-75(71,72)18-4-2/h5-16,19-20,23-24,37-38,63-64H,3-4,17-18,21-22,25-28H2,1-2H3,(H,57,65)(H,58,66)(H,59,61)(H,60,62) |
| InChIKey | OQHNUZDJTPNINN-UHFFFAOYSA-N |
| SMILES | FC1=CC=C(NS(CCC)(=O)=O)C(F)=C1C(C2CNC3=C2C=C(C4=CC=C(CNC(COCC(NCC(C=C5)=CC=C5C6=CC7=C(N=C6)NCC7C(C8=C(F)C(NS(CCC)(=O)=O)=CC=C8F)=O)=O)=O)C=C4)C=N3)=O |
| Reference | Discovery of Selective Small Molecule Degraders of BRAF-V600E |
