For research use only. Not for therapeutic Use.
<span style=”color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>Venadaparib (IDX-1197) (Cat.No:I020710) is a potent, selective and orally active </span><span style=”font-weight: 700; color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>PARP</span><span style=”color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”> inhibitor with </span><span style=”font-weight: 700; color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>IC<sub style=”position: relative; display: inline-block; font-size: 0.9em; line-height: 12px; font-weight: 300; transform: scale(0.8); top: 0px;”>50</sub></span><span style=”color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>s of 1.4 nM and 1.0 nM for </span><span style=”font-weight: 700; color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>PARP1</span><span style=”color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”> and </span><span style=”font-weight: 700; color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>PARP2</span><span style=”color: rgb(51, 21, 21); font-family: Arial, -apple-system, sans-serif; font-size: 14px; text-align: justify;”>, respectively. Venadaparib does not sensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSB) and can be used for solid tumors research.</span>
| Catalog Number | I020710 |
| CAS Number | 1681017-83-3 |
| Molecular Formula | C23H23FN4O2 |
| Purity | ≥95% |
| Target | Epigenetics |
| IUPAC Name | 4-[[3-[3-[(cyclopropylamino)methyl]azetidine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one |
| InChI | InChI=1S/C23H23FN4O2/c24-20-8-5-14(10-21-17-3-1-2-4-18(17)22(29)27-26-21)9-19(20)23(30)28-12-15(13-28)11-25-16-6-7-16/h1-5,8-9,15-16,25H,6-7,10-13H2,(H,27,29) |
| InChIKey | YNBQAYKYNYRCCA-UHFFFAOYSA-N |
| SMILES | C1CC1NCC2CN(C2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F |
