VER-50589

• CAT Number: I004774
• CAS Number: 747413-08-7
• Molecular Formula: C19H17ClN2O5
• Molecular Weight: 388.80
• Purity: ≥95%
• Synonyms: 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide
• Target: Hsp90
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: -20°C
• IC50: 21 nM
• IUPAC Name: 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide
• InChI: InChI=1S/C19H17ClN2O5/c1-3-21-19(25)17-16(10-4-6-11(26-2)7-5-10)18(27-22-17)12-8-13(20)15(24)9-14(12)23/h4-9,23-24H,3H2,1-2H3,(H,21,25)
• InChIKey: JXPCDMPJCKNLBY-UHFFFAOYSA-N
• SMILES: CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)OC)C3=CC(=C(C=C3O)O)Cl

VER-50589（Cat No.:I004774）is a selective inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone involved in the stabilization and activation of various client proteins, including those linked to cancer progression. By inhibiting Hsp90, VER-50589 disrupts the function of oncogenic proteins, leading to the degradation of proteins essential for tumor growth and survival. Its targeted mechanism makes VER-50589 a valuable compound for studying cancer biology and developing potential therapeutic strategies. It has shown promise in preclinical studies as a potential anti-cancer agent, particularly for malignancies driven by Hsp90-dependent pathways.

Reference

[1]. Sharp SY, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007 Apr;6(4):1198-211.
[2]. Gaspar N, et al. Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. Cancer Res. 2009 Mar 1;69(5):1966-75.