For research use only. Not for therapeutic Use.
Verapamil-d3 Hydrochloride (CAS: 2714485-49-9), a premium pharmaceutical research compound designed for advanced cardiovascular and antihypertensive studies. As a deuterated analog of Verapamil hydrochloride, it offers enhanced stability and improved pharmacokinetic properties. Verapamil-d3 Hydrochloride is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies for hypertension and cardiac conditions. Trusted by leading laboratories, Verapamil-d3 Hydrochloride is your go-to solution for cutting-edge cardiovascular research. Unlock new possibilities in heart disease treatment with Verapamil-d3 Hydrochloride, where innovation meets reliability.
| Catalog Number | S000146 |
| CAS Number | 2714485-49-9 |
| Molecular Formula | C27H36D3ClN2O4 |
| Purity | ≥95% |
| IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-(trideuteriomethyl)amino]-2-propan-2-ylpentanenitrile;hydrochloride |
| InChI | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H/i3D3; |
| InChIKey | DOQPXTMNIUCOSY-FJCVKDQNSA-N |
| SMILES | [2H]C([2H])([2H])N(CCCC(C#N)(C1=CC(=C(C=C1)OC)OC)C(C)C)CCC2=CC(=C(C=C2)OC)OC.Cl |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746. [3]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S. [4]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567. [5]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81. [6]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93. |
