Verapamil hydrochloride

• CAT Number: A000837
• CAS Number: 152-11-4
• Molecular Formula: C27H38N2O4.HCl
• Molecular Weight: 491.07
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: >14.5mg/mL in DMSO
• Storage: Store at -20C
• IUPAC Name: 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
• InChI: InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• InChIKey: DOQPXTMNIUCOSY-UHFFFAOYSA-N
• SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl

Verapamil hydrochloride ( CAS 152-11-4) is the hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.

Reference

1.McTavish, Donna, and Eugene M. Sorkin. "Verapamil." Drugs 38.1 (1989): 19-76.
2.Singh, Bramah N., Gray Ellrodt, and C. Thomas Peter. "Verapamil: a review of its pharmacological properties and therapeutic use." Drugs 15.3 (1978): 169-197.
3.Wang, Feihu, et al. "Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel-polymer micelles to overcome multi-drug resistance." Biomaterials 32.35 (2011): 9444-9456.
4.Futscher, Bernard W., et al. "Verapamil suppresses the emergence of P‐glycoprotein‐mediated multi‐drug resistance." International journal of cancer 66.4 (1996): 520-525.