For research use only. Not for therapeutic Use.
Verapamil (Cat No.: I015586) is a calcium channel blocker commonly used to treat hypertension, angina, and certain arrhythmias. By blocking L-type calcium channels, it reduces calcium influx in cardiac and smooth muscle cells, resulting in decreased heart rate and blood pressure. Verapamil’s negative chronotropic and inotropic effects slow conduction through the atrioventricular node, proving beneficial for supraventricular tachycardias. Additionally, it can relax vascular smooth muscle, improving blood flow. Potential side effects include hypotension, bradycardia, dizziness, and constipation, requiring patient monitoring and dose adjustment.
| CAS Number | 52-53-9 |
| Molecular Formula | C₂₇H₃₈N₂O₄ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile |
| InChI | 1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3 |
| InChIKey | SGTNSNPWRIOYBX-UHFFFAOYSA-N |
| SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC |
| Reference | [1]. Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25(3):743-746.<br>[2]. Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.<br>[3]. Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81.<br>[4]. Kubo Y, et al. Blood-to-Retina Transport of Fluorescence-Labeled Verapamil at the Blood-Retinal Barrier. Pharm Res. 2018 Mar 12;35(5):93.<br>[5]. Zhou P, et al. Anti-arrhythmic effect of Verapamil is accompanied by preservation of cx43 protein in rat heart. PLoS One. 2013 Aug 12;8(8):e71567. |
