For research use only. Not for therapeutic Use.
<p>As an analog of <strong>Veratridine</strong>, it is a Na<sup>+</sup> channel activator and a potent neurotoxic. Indeed, it is a depolarizing agent on membranes of nerve terminal, muscle and gland cells.</p><br />Steroid alkaloid<!–C<SUB>36</SUB>H<SUB>51</SUB>NO<SUB>10</SUB>–>, from plants of the <I>Veratrum </I>genus, Liliaceae</br><p>It has an effect on cardiac vessel system at the dosage of 1-50 μg/kg (i.v.)</p></br>
| Catalog Number | T000133 |
| CAS Number | 31329-58-5 |
| Synonyms | 4,9-Epoxycevane-3-beta,4-beta,14,15-alpha,16-beta,20-hexol 3-veratrate |
| Molecular Formula | C36H51NO10 |
| Purity | ≥95% |
| Solubility | In chloroform and methanol pyridine<br>Not well in ethanol, chloroform, water, acetone |
| Storage | Store at +4C, in dark place. Stable in freeze-dried state. Stable several months in solution. |
| Reference | – Kupchan. /Veratrum alkaloids. XXX. The structure and configuration of zygadenine./ J. Amer. Chem. Soc. (1959). 81:1925<br /><br />- Fink et al., /Veratridine and other depolarizing agents counteract the inhibitory effect of Mg++ ion…/Nannyn-Schmiedeberg�s Arch. Pharmacol. (1990). 342N(1):53-60<br /><br />- Tarvin et al., /Glucose induced electrical activity in the pancreatic beta-cells: effect of veratridine./ Amer. J. Physiol. (1981). 240:127-134<br /><br />- Honerjager, /A neutrally mediated inotropic effect of veratridine and sevadine on isolated guinea pig papillary muscle./ Nannyn Schmiederberg/’s Arch. Pharmacol. (1980). 314:157-160<br /><br /><br /><br /> |
