Verazide

• CAT Number: I038006
• CAS Number: 93-47-0
• Molecular Formula: C15H15N3O3
• Molecular Weight: 285.3
• Purity: 98%
• Synonyms: Verazide; Nicotazide; NSC180261; NSC-180261; NSC 180261
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (E)-N'-(3,4-dimethoxybenzylidene)isonicotinohydrazide
• InChI: InChI=1S/C15H15N3O3/c1-20-13-4-3-11(9-14(13)21-2)10-17-18-15(19)12-5-7-16-8-6-12/h3-10H,1-2H3,(H,18,19)/b17-10+
• InChIKey: HPXIKMBHOXLFOR-LICLKQGHSA-N
• SMILES: COc1c(OC)cc(/C=N/NC(c2ccncc2)=O)cc1

Verazide is a Tuberculostatic

Reference

1: RUBBO SD, CYMERMAN-CRAIG J. Anti-tuberculous activity of verazide (1-isonicotinoyl-2-veratrylidene hydrazine). Nature. 1955 Nov 5;176(4488):887. doi: 10.1038/176887a0. PMID: 13272716.
2: RUBBO SD, ROUCH LC, EGAN JB, WADDINGTON AL, TELLESSON WG. Chemotherapy of tuberculosis. III. Verazide in the treatment of pulmonary tuberculosis. Am Rev Tuberc. 1958 Aug;78(2):251-8. doi: 10.1164/artpd.1958.78.2.251. PMID: 13559656.
3: RUBBO SD, EDGAR J, VAUGHAN G. Chemotherapy of tuberculosis. I. Antituberculous activity of verazide and related hydrazones. Am Rev Tuberc. 1957 Sep;76(3):331-45. doi: 10.1164/artpd.1957.76.3.331. PMID: 13458717.
4: BARBOLINI G, LOSCHI GC. [Clinico-biological observations on the use of verazide in the therapy of pulmonary tuberculosis]. Clin Ter. 1961 Mar;20:253-73. Italian. PMID: 13686822.
5: RUBBO SD, VAUGHAN G. Chemotherapy of tuberculosis. II. Some observations on the pharmacology of verazide. Am Rev Tuberc. 1957 Sep;76(3):346-59. doi: 10.1164/artpd.1957.76.3.346. PMID: 13458718.