Vercirnon

• CAT Number: I004622
• CAS Number: 698394-73-9
• Molecular Formula: C22H21ClN2O4S
• Molecular Weight: 444.93
• Purity: ≥95%
• Target: Immunology/Inflammation
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: <7 nM (Molt-4 cells, CCR9 transfected cell, primary derived human T cells, and murine and rat thymocytes)
• IUPAC Name: 4-tert-butyl-N-[4-chloro-2-(1-oxidopyridin-1-ium-4-carbonyl)phenyl]benzenesulfonamide
• InChI: InChI=1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3
• InChIKey: JRWROCIMSDXGOZ-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C=C(C=C2)Cl)C(=O)C3=CC=[N+](C=C3)[O-]

Vercirnon(CAT: I004622) is a selective antagonist of CCR9, a chemokine receptor integral to T-cell trafficking and inflammation regulation. By inhibiting CCR9, Vercirnon disrupts the migration of inflammatory cells to the gastrointestinal tract, offering significant potential in inflammatory bowel disease (IBD) research, particularly Crohn’s disease. Its targeted mechanism helps elucidate the role of CCR9 in chronic inflammation and gut homeostasis. Vercirnon is a valuable tool for exploring therapeutic strategies aimed at modulating immune cell dynamics. With its precision and efficacy, Vercirnon is a cornerstone in advancing inflammation and immunology research and therapeutic innovation.