Verdinexor (KPT-335)

• CAT Number: I010017
• CAS Number: 1392136-43-4
• Molecular Formula: C18H12F6N6O
• Molecular Weight: 442.32
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: C1=CC=NC(=C1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor.

Reference

[1] London CA, et al. PLoS One. 2014, 9(2), e87585.
[2] Perwitasari O, et al. J Virol. 2014, 88(17), 10228-10243.
[3] Tan M, et al. Am J Physiol Renal Physiol. 2014, 307(11), F1179-F1186.