For research use only. Not for therapeutic Use.
Vericiguat（Cat No.:I010019）is an oral soluble guanylate cyclase (sGC) stimulator used to treat heart failure with reduced ejection fraction (HFrEF). It works by enhancing the production of cyclic guanosine monophosphate (cGMP), leading to vasodilation and improved cardiac function. Vericiguat specifically targets the nitric oxide signaling pathway, helping to reduce the risk of heart failure-related hospitalization and cardiovascular death. Its ability to improve heart function and quality of life in patients with chronic heart failure makes it an important therapeutic option, particularly for those with worsening symptoms despite standard treatments.
| Catalog Number | I010019 |
| CAS Number | 1350653-20-1 |
| Synonyms | BAY1021189; BAY 1021189; BAY-1021189; BAY10-21189; BAY-10-21189; BAY 10-21189; Vericiguat.;methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate |
| Molecular Formula | C19H16F2N8O2 |
| Purity | 98% |
| Target | Guanylate Cyclase |
| Target Protein | Q02153 |
| Solubility | Soluble in DMSO, not in water |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| Overview of Clinical Research | <p> |
| IUPAC Name | methyl N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate |
| InChI | InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27) |
| InChIKey | QZFHIXARHDBPBY-UHFFFAOYSA-N |
| SMILES | COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N |
| Reference | 1.Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study. Pieske B, Maggioni AP, Lam CSP, Pieske-Kraigher E, Filippatos G, Butler J, Ponikowski P, Shah SJ, Solomon SD, Scalise AV, Mueller K, Roessig L, Gheorghiade M.Eur Heart J. 2017 Apr 14;38(15):1119-1127. doi: 10.1093/eurheartj/ehw593. PMID: 28369340 Free PMC Article<br /> |
