Vernakalant Hydrochloride

• CAT Number: I004779
• CAS Number: 748810-28-8
• Molecular Formula: C20H32ClNO4
• Molecular Weight: 385.93
• Purity: ≥95%
• Synonyms: (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol;hydrochloride
• Target: Potassium Channel
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C20H31NO4.ClH/c1-23-19-8-7-15(13-20(19)24-2)10-12-25-18-6-4-3-5-17(18)21-11-9-16(22)14-21;/h7-8,13,16-18,22H,3-6,9-12,14H2,1-2H3;1H/t16-,17-,18-;/m1./s1
• InChIKey: JMHYCBFEEFHTMK-IIUXMCBISA-N
• SMILES: COC1=C(C=C(C=C1)CCOC2CCCCC2N3CCC(C3)O)OC.Cl

Vernakalant hydrochloride（Cat No.:I004779） is a compound that acts as a mixed voltage- and frequency-dependent blocker of sodium (Na+) and potassium (K+) channels. It specifically inhibits the Kv1.5 channels, Kv1.5 channelI508F, and Kv1.5 channelT479A with half-maximal inhibitory concentration (IC50) values of 13.35±0.93 μM. By blocking these channels, vernakalant interferes with the electrical signaling in cardiac tissue, potentially suppressing abnormal or rapid heart rhythms.

Reference

[1]. Dorian, Paul MD et al. The Effect of Vernakalant (RSD1235), an Investigational Antiarrhythmic Agent, on Atrial Electrophysiology in Humans. Journal of Cardiovascular Pharmacology:July 2007 – Volume 50 -Issue 1 – pp 35-40.
[2]. Jodene Eldstrom et al. The Molecular Basis of High-Affinity Binding of the Antiarrhythmic Compound Vernakalant (RSD1235) to Kv1.5 Channels. Molecular Pharmacology December 2007 vol. 72 no. 6 1522-1534