Verubecestat TFA

• CAT Number: I014753
• CAS Number: 2095432-65-6 (TFA)
• Molecular Formula: C19H18F5N5O5S
• Molecular Weight: 523.435
• Purity: ≥95%
• Synonyms: MK-8931; MK 8931; MK8931; MK-8931-009; SCH 900931; SCH-900931; SCH900931; Verubecestat TFA;;(R)-N-(3-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide trifluoroacetic acid
• Target: Beta-Secretase Inhibitor
• Solubility: Soluble in DMSO, not in water
• InChI: InChI=1S/C17H17F2N5O3S.C2HF3O2/c1-17(9-28(26,27)24(2)16(20)23-17)12-7-11(4-5-13(12)19)22-15(25)14-6-3-10(18)8-21-14;3-2(4,5)1(6)7/h3-8H,9H2,1-2H3,(H2,20,23)(H,22,25);(H,6,7)/t17-;/m0./s1
• InChIKey: MNYVOIVLGITLBF-LMOVPXPDSA-N
• SMILES: O=C(NC1=CC=C(F)C([C@@](C2)(C)N=C(N)N(C)S2(=O)=O)=C1)C3=NC=C(F)C=C3.O=C(O)C(F)(F)F

Verubecestat TFA(CAT: I014753) is a trifluoroacetic acid salt form of Verubecestat. Verubecestat is a potent and selective inhibitor of beta-secretase 1 (BACE1), an enzyme involved in the production of amyloid-beta peptides, which are known to accumulate in the brains of individuals with Alzheimer’s disease. By inhibiting BACE1, Verubecestat TFA has the potential to reduce the production of amyloid-beta peptides and potentially slow down the progression of Alzheimer’s disease.

Reference

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