(-)-Vesamicol

• CAT Number: M030383
• CAS Number: 112709-59-8
• Molecular Formula: C17H25NO
• Molecular Weight: 259.39
• Purity: ≥95%
• Synonyms: (1R,2R)-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol
• InChI: InChI=1S/C17H25NO/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14/h1-3,6-7,15-17,19H,4-5,8-13H2/t16-,17-/m1/s1
• InChIKey: YSSBJODGIYRAMI-IAGOWNOFSA-N
• SMILES: C1CCC(C(C1)N2CCC(CC2)C3=CC=CC=C3)O

(-)-Vesamicol (Cat No.: M030383) is a selective inhibitor of the vesicular acetylcholine transporter (VAChT), which plays a crucial role in packaging acetylcholine into synaptic vesicles. By blocking VAChT, (-)-Vesamicol reduces the release of acetylcholine, a neurotransmitter involved in muscle contraction, cognition, and various autonomic processes. It is commonly used in neuroscience research to study cholinergic neurotransmission and its role in diseases such as Alzheimer’s, Parkinson’s, and other neurodegenerative disorders. (-)-Vesamicol has potential applications in developing therapies targeting cholinergic dysfunction.

Reference

[1]. Searl T, et al. Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium. J Physiol. 1991;444:99-116.
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