Vesnarinone

• CAT Number: I004968
• CAS Number: 81840-15-5
• Molecular Formula: C22H25N3O4
• Molecular Weight: 395.45
• Purity: ≥95%
• Target: Phosphodiesterase (PDE)
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 1.1 μM (for HERG current)
• IUPAC Name: 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
• InChI: InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
• InChIKey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C(=O)N2CCN(CC2)C3=CC4=C(C=C3)NC(=O)CC4)OC

Vesnarinone（Cat No.:I004968）is an inotropic and vasodilatory agent primarily used in the treatment of heart failure. It works by inhibiting the enzyme phosphodiesterase III (PDE3), leading to an increase in intracellular cyclic AMP (cAMP), which enhances cardiac contractility and promotes vasodilation. This helps improve blood flow and reduce the workload on the heart. Vesnarinone also has anti-inflammatory effects that may contribute to its efficacy in managing heart failure. Though it has shown positive effects in clinical trials, its use has been limited due to potential side effects, such as arrhythmias, and safety concerns.