VH032-cyclopropane-F

• CAT Number: I018102
• CAS Number: 2306193-99-5
• Molecular Formula: C₂₆H₃₃FN₄O₅S
• Molecular Weight: 532.63
• Purity: ≥95%
• Target: Ligands for E3 Ligase

VH032-cyclopropane-F (Cat.No:I018102) is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1].

Reference

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.