VH032-PEG5-C6-Cl

• CAT Number: I020029
• CAS Number: 1799506-06-1
• Molecular Formula: C₃₈H₅₉ClN₄O₉S
• Molecular Weight: 783.41
• Purity: ≥95%
• Target: E3 Ligase Ligand-Linker Conjugates
• IUPAC Name: (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-(6-chlorohexoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C38H59ClN4O9S/c1-28-34(53-27-41-28)30-11-9-29(10-12-30)24-40-36(46)32-23-31(44)25-43(32)37(47)35(38(2,3)4)42-33(45)26-52-22-21-51-20-19-50-18-17-49-16-15-48-14-8-6-5-7-13-39/h9-12,27,31-32,35,44H,5-8,13-26H2,1-4H3,(H,40,46)(H,42,45)/t31-,32+,35-/m1/s1
• InChIKey: ADYHVGXLTSRLTE-MEEYNGGZSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCOCCOCCCCCCCl)O

VH032-PEG5-C6-Cl（Cat No.:I020029）is a specialized chemical compound designed for use in drug delivery and bioengineering applications. It consists of a VH032 ligand (a small molecule with specific binding properties), linked to a polyethylene glycol (PEG) chain of five ethylene glycol units (PEG5), and a six-carbon (C6) alkyl chain, with a chlorine atom (Cl) attached. This structure is typically used to improve the solubility, stability, and bioavailability of therapeutic molecules. The PEG component enhances the compound’s water solubility, while the C6 and VH032 moieties provide specific binding and targeting capabilities, useful in targeted therapies or diagnostic applications.

Reference

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.